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Siraitia Grosvenorii
Siraitia grosvenorii is an herbaceous perennial vine native to southern People's Republic of China and Northern
Thailand and best known for its fruit, the luo han guo (traditional Chinese:
羅漢果/simplified Chinese: 罗汉果;
pinyin: luóhàn guǒ; literally "arhat fruit" or monk's fruit). It is one of four species in the genus Siraitia. Botanical
synonyms include Momordica grosvenorii and Thladiantha grosvenorii. The fruit is one of several that have been
called longevity fruit.[1]

The other species of the genus Siraitia are: S. siamensis from Thailand, S. sikkimensis and S. silomaradjae
from India, and S. taiwaniana from the Republic of China (Taiwan).

The vine grows to 3 to 5 m long, climbing over other plants by means of tendrils which twine round anything they
touch. The narrow, heart-shaped leaves are 10–20 cm long. The fruit is globose, 5–7 cm in diameter, and
contains a sweet, fleshy, edible pulp and numerous seeds.

The fruit extract is nearly 300 times sweeter than sugar and has been used as a natural sweetener in China for
nearly a millennium due to its flavor and lack of food energy, only 2.3 kcal/g (9.6 kJ/g). It has also been used in
traditional Chinese medicine.[2]
Scientific classification

Binomial name
  • Siraitia grosvenorii
Siraitia grosvenorii (luohan guo) fruits

It is grown primarily in the southwestern Chinese province of Guangxi (mostly in the mountains of Guilin), as well
as in Guangdong, Guizhou, Hunan, and Jiangxi. These mountains lend the plants shadows and often are
surrounded by mists; because of this the plants are protected from the sun. Nonetheless, the climate in this
southern province is warm. The plant is rarely found in the wild and has hence been cultivated for hundreds of
Records as early as 1813 mention the cultivation of this plant in the Guangxi province.[3] At present, the Guilin mountains harbor a plantation of 16 square kilometers with a
yearly output of about 10,000 fruits. Most of the plantations are located in Yongfu County and Lingui County, which in China are renowned for the extraordinary number of
centenarians. This is usually attributed to the consumption of this fruit and the unspoiled nature. The inhabitants themselves, however, are of the opinion that the reason lies
in their calm lifestyle and simple nutrition.

Longjiang town ("Dragon River") in Yongfu County has acquired the name "home of the Chinese luohanguo fruit"; a number of companies specialised in making luohanguo
extracts and finished products have been set up in the area. The Yongfu Pharmaceutical Factory is the oldest of these.

Traditional uses

The plant is most prized for its sweet fruits, which are used for medicinal purposes, and as a sweetener.[4] The fruits are generally sold in dried form, and traditionally used
in herbal tea or soup. They are used for respiratory ailments, sore throats and reputed to aid longevity.[5]

The best way to describe the medicinal use of luohan guo in southern China during the 20th century can be found in the book [6] written by Dai and Liu. It was written in
Chinese in 1982 and translated into English in 1986. Here is their description:

The dried fruit may be bought in a market. The surface of the fruit is round and smooth, it has a yellow-brownish or green-brownish colour, and is covered by fine hairs. The
fruit has a hard but thin shell. Inside, one finds a partially dried, soft substance which contains the juice and a large quantity of seeds. All components are very sweet. Their
nature is cool and not toxic. The fruit can act as a remedy for sun stroke, wet the lungs, remove phlegm, stop cough and aid defecation.[7]
Heat stroke and thirst
Take a fruit, break it open and pour hot water on it to make an infusion. Drink the infusion in place of tea.
Acute or chronic infection of the larynx (aphonia)
Take the halves of a fruit and 3 to 5 sterculia seeds, cover this with water and leave it to boil. Swallow very slowly.
Chronic cough
Take a piece of the fruit, cover it with water and leave it to boil. Drink the resulting liquid twice daily.
Constipation due to old age
Take two fruits and, using only the soft parts and seeds, divide it into pieces. Cover these pieces with water, boil it, and drink the liquid before going to bed.
Take an appropriate amount of fruit squash or boil it so as to get concentrated juice. Use this as a substitute for sugar in your nutrition..[8]
Active agents

The sweet taste of luohan guo comes mainly from the mogrosides, a group of
Triterpene-Glycosides that make up approximately 1% of the flesh of the fresh fruit.
Through extraction, a powder containing 80% mogrosides can be obtained.[9]

Five different mogrosides are known and they are known by names with the
numbers 1 to 5. The main mogroside in this plant is mogroside-5, that was
previously known as esgoside.[10]

Other similar agents in luohan guo are Siamenoside and Neomogroside.[11]

The pure mogroside mix present results in a sweetness that is 300 times sweeter
than sugar. The 80% mix is approximately 250 times sweeter. Pure mogroside-5
and -5 can be up to 400 times as sweet.


There are no reported incidents of negative side effects of luohan guo that are
known. It is classed by the American Food and Drug Administration as a GRAS
(generally recognized as safe) product. There are no restrictions on consuming the
fruit or its extracts.
Scientific classification

Binomial name
  • Siraitia grosvenorii
Structural formula of mogroside 5
Current research

Recent research on luohan guo suggests that the mogroside works as an antioxidant[12] and that it helps to prevent cancer.[13][14]

The use of luohan guo as a remedy for diabetes and overweight has been mentioned, as it can be used as a substitute for sugar.[15]

Luohan guo has been shown to be useful against the Epstein-Barr virus. [16]

The plant also contains a glycoprotein called momorgrosvin, which has been shown to inhibit ribosomal protein synthesis[17]
Dried Siraitia grosvenorii fruit, cut open
Cultivation and marketing

[edit] Traditional processing

Luohan guo is harvested in the form of a round green fruit, which becomes brown on drying. It is rarely used in its
fresh form, as it is hard to store. Furthermore, it develops a rotten taste on fermentation, which adds to the
unwanted flavours already present.

Thus the fruits are usually dried before further use and are sold in precisely this fashion in Chinese herbal
shops. The fruits are slowly dried in ovens, which preserves it and removes most of the unwanted aromas.
However, this technique also leads to the formation of several bitter and astringent aromas. This limits the use of
the dried fruits and extracts to the preparation of diluted tea, soup, and as a sweetener for products that would
usually have sugar or honey added to them.[18]

The Procter & Gamble process

The process for the manufacture of a useful sweetener from luohan guo was patented in 1995 by Procter &
Gamble. The patent states that, while luohan guo is very sweet, it has too many interfering aromas, which render
it useless for general application. Thus the company developed a process for the removal of the interfering

In this process, the fresh fruit is harvested before it is fully mature, and is then matured in storage so that it may
be processed precisely when it is mature. The shell and seeds are then removed, and the pulped fruit is made
into a fruit concentrate or puree. This is then used in the further production of food. Solvents are used, amongst
other things, to remove the interfering aromas.


There are a number of commercially prepared luohan guo products:

One of the most famous ones is powdered instant luohan guo, which is also sold by the Yongfu company. It is
sold in China, Hong Kong and in Chinese shops in the West.

In addition, there are a number of other products which contain luohan guo either on its own or in a mix with other
herbs. For example it is used with Ginkgo against cough, with chrysanthemum against heatstroke and headache
or with asparagus, Oldenlandia, Scutellaria, and pearl powder to detoxify.
During the Tang dynasty, Guilin was one of the most important Buddhist retreats containing many temples. The fruit was named after the arhats (Chinese: 罗汉; pinyin: luóhàn), a group of Buddhist
monks who, due to their proper way of life and meditation, achieved enlightenment and were said to have been redeemed. According to Chinese history, the fruit was first mentioned in the records of
the 13th century monks who used it.

However, plantation space was limited: it existed mainly in the slopes of the Guangxi and Guangdong mountains, and to a lesser degree in Guizhou, Hunan, Jiangxi, and Hainan. This and the difficulty
of cultivation meant that the fruit did not become part of the Chinese herbal tradition, which depended on more readily available products. This is also the reason why one finds no mention of it in the
traditional guides to herbs.

Rediscovery in the 20th century

The herb became better known in the 20th century. The first report on the herb in English was found in an unpublished manuscript written in 1938 by Professor G. W. Groff and Hoh Hin Cheung. The
report stated that the fruits were often used as the main ingredients of "cooling drinks," that is, as remedies for hot weather, fever, or other dysfunctions traditionally associated with warmth or heat.

It was known that the juice of the fruits was very sweet.

Groff and Hoh realised that the fruit was an important Chinese domestic remedy for the treatment of cold and pneumonia when consumed with pork.

Interviews have confirmed that the fruit only recently gained importance in Chinese history. Nonetheless, it appears that a small group of people had mastered its cultivation a long time ago and had
accumulated extensive knowledge on growth, pollination, and climatic requirements of the plant.

The fruit came to the United States in the early 20th century. Groff mentions that during a visit to the American ministry of agriculture in 1917, the botanic Frederick Coville showed him a luohanguo fruit
bought in a Chinese shop in Washington. Seeds of the fruit which had been bought in Chinese shop in San Francisco were entered into the universal botanic description of the species in 1941.

The first research into the sweet component of luohanguo is attributed to C. H. Lee, who wrote an English report on it in 1975, and also to Tsunematsu Takemoto, who worked on it the early 1980s in
Japan (later Takemoto decided to concentrate on the similar sweet plant, jiaogulan).

The development of luohanguo products in China has continued ever since, focusing in particular on the development of concentrated extracts.


Much of the content of this article comes from the equivalent German-language Wikipedia article (retrieved February 16, 2006).

  1. ^ Ling Yeouruenn, A New Compendium of Materia Medica, 1995 Science Press, Beijing.
  2. ^ Ling Yeouruenn, A New Compendium of Materia Medica, 1995 Science Press, Beijing.
  3. ^ Dragon River Health Products,
  4. ^ Kinghorn AD and Soejarto DD, Discovery of terpenoid and phenolic sweeteners from plants, Pure Applied Chemistry 2002; 74(7): 1169-1179.
  5. ^ Dai Yinfang and Liu Chengjun, Fruit as Medicine, 1986 The Ram's Skull Press, Kuranda, Australia.
  6. ^ Fruit as a medicine
  7. ^ Fruits As Medicine: A Safe and Cheap Form of Traditional Chinese Food Therapy by Dai Yin-Fang, Liu Cheng-Jun, translated by Ron Edwards, and Gong Zhi-Mei 1986
  8. ^ Fruits As Medicine: A Safe and Cheap Form of Traditional Chinese Food Therapy by Dai Yin-Fang, Liu Cheng-Jun, translated by Ron Edwards, and Gong Zhi-Mei 1986
  9. ^ Subhuti Dharmananda, Ph.D., Director, Institute for Traditional Medicine, Portland, Oregon Luo Han Guo -Sweet Fruit Used as Sugar Substitute
    and Medicinal Herb
  10. ^ Subhuti Dharmananda, Ph.D., Director, Institute for Traditional Medicine, Portland, Oregon
  11. ^ Subhuti Dharmananda, Ph.D., Director, Institute for Traditional Medicine, Portland, Oregon Luo Han Guo -Sweet Fruit Used as Sugar Substitute
    and Medicinal Herb
  12. ^ Shi H, et al., Antioxidant property of fructus momordicae extract, 1996 Biochemistry and Molecular Biology International 1996; 40 (6): 1111-1121.
  13. ^ Konoshima T and Takasaki M, Cancer-chemopreventive effects of natural sweeteners and related compounds, Pure Applied Chemistry 2002; 74(7): 1309-1316. [1]
  14. ^ Katiyar SK and Mukhtar H, Tea antioxidants in cancer chemoprevention, Journal of Cellular Biochemistry, Supplement 1997; 27: 59-67.
  15. ^ Subhuti Dharmananda, Ph.D., Director, Institute for Traditional Medicine, Portland, Oregon Luo Han Guo Sweet Fruit Used as Sugar Substitute
    and Medicinal Herb
  16. ^ Akihisa T, Hayakawa Y, Tokuda H, Banno N, Shimizu N, Suzuki T, Kimura Y.
    Cucurbitane Glycosides from the Fruits of Siraitia grosvenorii and Their Inhibitory Effects on Epstein-Barr Virus Activation. J Nat Prod. 2007 May 25;70(5):783-788. Epub 2007
  17. ^ Tsang, K.Y. and T.B. Ng (2001). "Isolation and characterization of a new ribosome inactivating protein, momorgrosvin, from seeds of the monk's fruit Momordica grosvenorii". Life Sciences 68:
    773–784. doi:10.1016/S0024-3205(00)00980-2.  
  18. ^ Hsu HY, et al., Oriental Materia Medica, 1986 Oriental Healing Arts Institute, Long Beach, California

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